Cychlorphine - DOWNLOAD PDF INFO SHEET

• Cychlorphine is a synthetic opioid.
• It is typically found in counterfeit pills sold under names like hydromorphone (Dilaudid), oxycodone (OxyContin) and Percocet. It can also be found in drugs sold as crushed powder.
• It has been found mixed with other opioids, or with stimulants like cocaine and meth. Mixing drugs increases the risk of overdose.
• Because cychlorphine is an opioid, naloxone can reverse it. However, cychlorphine may require more doses.
• Cychlorphine is not approved for use in humans. It is thought to be 10 times stronger than fentanyl.
• It first appeared in the drug supply in Canada in Toronto in 2025. In December 2025 it was found in a blue tablet sold as Percocet in Thunder Bay, and in June 2026 it was found in a white tablet sold as Percocet.
• Cychlorphine is part of a group of synthetic opioids called “orphines.” Chemically, orphines are similar to fentanyl and nitazenes.

Sources:

Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine
(Cychlorphine), Center for Forensic Science Research and Education, United States.

Unregulated fentanyl supply trends: Toronto, Ontario
October 18 – 31, 2025, Toronto's Drug Checking Service, Canada.

The emerging threat of cychlorphine: A new synthetic opioid raising concerns globally for public health, United Nations Office on Drugs and Crime, Austria.